Drawing its title from James W. Moore’s idea of “singular metabolism,” which insists on the deeply enfolded nature of social and environmental phenomena, this reading event explores how the exploitation of natural resources is connected to colonization, white supremacy, and a globalization powered by capitalism. These artists and poets, sharing a concern for how discourses around the Anthropocene can obscure social and political structures of power, offer complex interpretations of the historical link between ecological plunder and social injustice. The deep interconnectedness of social life and geological transformation—whether understood as the age of the Anthropocene or not—will require diverse and agile re-imaginings of the human’s relationship to nature and each other. Taking the idea of singular metabolism seriously, artistic reactions to a changing world are as necessary as economic or ecological tactics, and amongst these performances, adequate responses take root.